The Champions League tie is a real possibility, with Dortmund needing just one point to qualify for next season’s quarter-finals.
With a victory, the hosts will clinch a spot in the last 16 and end a five-match run without defeat, with the tie set to be broadcast on television.
However, there is also the chance that the two sides could end up with just one victory, and the game could go to penalties.
Here are our five possible scenarios.
Borussia Dortmund – 1-1 Borussia 04-04, 5.20pm (AEST) Real Madrid have scored six goals in the first half of their two matches in the Champions League this season.
They have scored three in the opening two minutes and one in the 33rd minute.
With the German champions holding a four-goal lead, a first-half goal is likely.
The visitors will be hoping that they can put Dortmund under the impression that they are the better side in the game, especially with the hosts’ number of goals conceded in this competition this season coming on the back of seven in the Bundesliga.
With Mario Gotze, Henrikh Mkhitaryan and Kevin de Bruyne on the pitch, Dortmund have the potential to make it three in a row in the match.
Real Madrid – 0-0 BVB, 7.45pm (EST) The two sides have never met since the 2007-08 season, when Dortmund beat the Catalan giants 1-0 in the quarter-final of the Champions Leagues.
They had to wait until the 2013-14 season for their next encounter, with Ronaldo’s Real Madrid team scoring a third-minute winner to claim the Champions Cup in 2016.
In that match, the Portuguese club conceded the winner, a penalty kick, in the 90th minute.
There is no doubt that this is a tough fixture, but Dortmund should take advantage of their opponents’ lack of experience and allow their attackers to play freely, with Mario Gotz and David Alaba on the bench.
They should be able to keep the ball down well, with David Alba having scored in the final five minutes of last season’s match.
What happens next?
1/5 Real Madrid 1-2 Borussia Real Madrid beat Borussia Borussia 4-2 on penalties in the 2011-12 season, but it was the last time the two teams met in the Europa League, when they won 3-2 in the group stage.
This is a crucial match, as the Champions’ League semi-finalists have a two-match lead in Group B, with Borussia looking to extend their advantage.
The game will be broadcast live on BT Sport, and Sky Sports will carry the game on BT Sports Extra.
What will be the result?
1-3 Real Madrid.
The Spaniards are the current holders of the European Cup and a UEFA Europa League trophy, but are yet to win the trophy in the competition.
They are currently in sixth place in Group A. What is the tie about?
Real Madrid are the reigning Champions League winners, having reached the last four four of the competition twice.
They were beaten by Juventus 3-1 in the semi-finals of last year’s competition, while the holders beat Borasik 3-0 at the Bernabeu.
They last won the competition in 2008-09, with a 4-1 win over Olympiakos in the second round.
The hosts have only conceded one goal in the three matches they have played so far this season, while Dortmund have conceded six.
The pair have not faced each other in the past four years, and will be looking to add to their three victories in the European competition.
What’s the line-up?
Borussia BVB are in the same group as Real Madrid, with both sides playing in the fifth tier of the Bundesliga, with Real Madrid in second and Borussia in third.
The two teams have met twice this season in the round of 16, with Bayern Munich winning 4-3 in Dortmund’s last outing and Real Madrid beating them 2-1 on penalties last time out.
This will be a tough match for the hosts, who have struggled to break down Dortmund in the league so far.
What are the odds?
Real Betis have a 50-50 chance of winning, with 10/1 to win.
Betis currently have the highest odds of winning the Champions league, at 15/1.
Borasis have the lowest odds of taking home the trophy, at 10/3.
How will the players perform?
The two clubs have been playing in very different styles in recent years, with Madrid winning the treble last year, and Boras failing to win it in two successive seasons.
However it is likely that the visitors will have the better players in this match, with Mkhijaž Mamic, Andre Gomes, Cristiano Ronaldo and Mario Gotzes all fit to play.
What to watch for: This game